Prof. Bernard Korzeniewski, PhD

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first 100 pages of the book





link to book website (Cambridge Scholars Publishing)







SCIENTIFIC RESEARCH:

• Computer modeling of animal cell energy metabolism

• Regulation of oxidative phosphorylation in skeletal muscle, heart and other tissues in response to elevated energy demand ('parallel-activation' or 'each-step-activation' proposal: all steps of oxidative phosphorylation are directly activated in parallel with ATP consumption and NADH supply by some external factor during an increased energy demand)

>>> Why are skeletal muscles not depleted of energy during intense exercise? LINK

• Mechanisms underlying muscle fatigue - self-driving "P_i double-threshold" mechanism (based on three assumptions: (1) additional ATP usage, underlying muscle VO₂ and metabolite slow components, is initiated when inorganic phosphate (P_i) exceeds a critical value (Pi_crit); (2) exercise is terminated because of fatigue, when P_i reaches a peak value (Pi_peak); (3) the P_i increase and additional ATP usage increase mutually stimulate each other forming a positive feedback)

• Training-induced changes in the skeletal muscle bioenergetic system

• Effect of low oxygen concentration on oxidative phosphorylation

• Effect of inborn enzyme deficincies on oxidative phosphorylation; genesis of mitochondrial diseases

• Cybernetic definition of life (a living individual)

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OTHER INTERESTS:

• Origin and essence of psyche and (self-)consciousness

• Integrated coherent theory of brain functioning

• Essence, origin and evolution of life

• Thermodynamic basis of life

• Essence and evolution of the Universe and physical level of reality

• Cognitive abilities of humans; status and limitations of the world view formed in the brain

• Philosophy of science

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